Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3651075 | 0.95 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2C19RECQLPOLB | |
| SCHEMBL3658110 | 0.89 | KDM4E (0.44) | CYP1A2CYP3A4CYP2C19POLBNPC1 | |
| Trifluoroacetic Acid SCHEMBL3653064 | 0.86 | KDM4E (0.42) | CYP1A2CYP3A4CYP2C19POLBNPC1 | |
| SCHEMBL3655137 | 0.83 | RAB9A (0.43) | RECQLNPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL3658418 | 0.83 | NPC1 (0.48) | POLBNPC1GAAKMT2AALDH1A1 | |
| SCHEMBL3659607 | 0.82 | LMNA (0.33) | RECQLKMT2ALMNAALDH1A1MEN1 | |
| Trifluoroacetic Acid SCHEMBL3655787 | 0.82 | MLYCD (0.46) | CYP1A2CYP2C19POLBNPC1RAB9A | |
| SCHEMBL3654285 | 0.80 | MAPT (0.38) | RAB9AKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL3656321 | 0.79 | KCNH2 (0.44) | POLBNPC1RAB9AKMT2ALMNA | |
| SCHEMBL3656206 | 0.79 | KCNH2 (0.44) | POLBNPC1RAB9AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |