Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203695 | 0.95 | LMNA (0.55) | MAPTLMNAKMT2AMEN1ALOX5 | |
| SCHEMBL2204261 | 0.94 | KMT2A (0.53) | MAPTLMNAKMT2AMEN1ALOX5 | |
| SCHEMBL3659810 | 0.89 | MAPT (0.50) | MAPTLMNAKMT2AMEN1ALOX5 | |
| SCHEMBL3652266 | 0.87 | KMT2A (0.50) | MAPTKMT2AMEN1ALOX5SMN1; SMN2 | |
| SCHEMBL27539635 | 0.86 | HPGD (0.50) | ALDH1A1 | |
| SCHEMBL8413418 | 0.84 | HTT (0.51) | MAPTKMT2AMEN1ALOX5SMN1; SMN2 | |
| SCHEMBL3652268 | 0.82 | KMT2A (0.49) | MAPTLMNAKMT2AMEN1ALOX5 | |
| SCHEMBL3664745 | 0.82 | POLB (0.50) | MAPTLMNAKMT2AMEN1ALOX5 | |
| SCHEMBL6162376 | 0.81 | ALOX5 (0.59) | MAPTLMNAKMT2AMEN1ALOX5 | |
| SCHEMBL3508583 | 0.81 | POLB (0.55) | MAPTKMT2AMEN1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205573-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009043780-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-09 | — | — | WO | disclosed |