Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203695 | 0.93 | LMNA (0.55) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3656808 | 0.89 | MAPT (0.52) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2204744 | 0.88 | ATAD2 (0.47) | SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL6606900 | 0.85 | NPC1 (0.52) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL2204261 | 0.82 | KMT2A (0.53) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3652268 | 0.80 | KMT2A (0.49) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3664745 | 0.80 | POLB (0.50) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL2491580 | 0.79 | NPC1 (0.54) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL3508583 | 0.79 | POLB (0.55) | MAPTKMT2AMEN1RAB9APOLB | |
| SCHEMBL1997115 | 0.79 | NPC1 (0.70) | MAPTLMNAKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205573-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009043780-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-09 | — | — | WO | disclosed |