Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 5/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.49 |
| ▸ | POLR1A | O95602 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | PTGFR | P43088 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365704 | 0.85 | KMT2A (0.52) | KMT2APTAFRTBXAS1KCNK3KCNH2 | |
| SCHEMBL366361 | 0.81 | S1PR3 (0.52) | KMT2AKDM4ETP53MAPT | |
| SCHEMBL364302 | 0.80 | KMT2A (0.48) | KMT2AKDM4EMTNR1AMTNR1BGAA | |
| SCHEMBL365564 | 0.74 | KMT2A (0.56) | KMT2AKDM4EGAAPOLBTP53 | |
| SCHEMBL24273319 | 0.73 | LMNA (0.52) | PTAFRKCNK3KCNH2KDM4ENAMPT | |
| SCHEMBL24273219 | 0.73 | PTGER4 (0.65) | KMT2APTAFRNAMPTGAAPOLB | |
| SCHEMBL365013 | 0.73 | KDM4E (0.58) | KMT2AKDM4EGAAPOLBTP53 | |
| SCHEMBL24273183 | 0.72 | KCNK3 (0.56) | KMT2AKCNK3KCNH2KDM4EMTNR1A | |
| SCHEMBL24273393 | 0.72 | PTGER4 (0.64) | KMT2APTAFRKCNK3KCNH2GAA | |
| SCHEMBL364593 | 0.72 | KMT2A (0.56) | KMT2AKDM4EGAAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |