Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 10/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 9/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3877454 | 1.00 | CYP1A2 (0.44) | CYP1A2CYP1A1CYP1B1TRIM24TYR | |
| SCHEMBL3877460 | 1.00 | CYP1A2 (0.44) | CYP1A2CYP1A1CYP1B1TRIM24TYR | |
| SCHEMBL3657050 | 1.00 | CYP1A2 (0.44) | CYP1A2CYP1A1CYP1B1TRIM24TYR | |
| SCHEMBL3657053 | 1.00 | CYP1A2 (0.44) | CYP1A2CYP1A1CYP1B1TRIM24TYR | |
| SCHEMBL13715487 | 0.79 | ALDH1A1 (0.42) | CYP1A2CYP1A1CYP1B1TRIM24TYR | |
| SCHEMBL28472704 | 0.77 | CYP1A2 (0.52) | CYP1A2CYP1A1CYP1B1TRIM24TYR | |
| SCHEMBL19766709 | 0.77 | CYP1A2 (0.52) | CYP1A2CYP1A1CYP1B1TRIM24TYR | |
| SCHEMBL3523915 | 0.76 | CDK4 (0.46) | KMT2AALOX5KDM4EMAPK1TDP1 | |
| SCHEMBL23620222 | 0.75 | CYP1A1 (0.50) | CYP1A2CYP1A1CYP1B1TRIM24TYR | |
| SCHEMBL17821560 | 0.75 | CYP1A2 (0.50) | CYP1A2CYP1A1CYP1B1TRIM24TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139843-A1 | SUBSTITUTED BIPHENYL PHENOXY-, THIOPHENYL- AND AMINOPHENYLPROPANOIC ACID GPR40 MODULATORS | Amgen, Inc (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008130514-A1 | SUBSTITUTED BIPHENYL PHENOXY-, THIOPHENYL- AND AMINOPHENYLPROPANOIC ACID GPR40 MODULATORS | AMGEN INC. (US) | 2008-10-30 | — | — | WO | disclosed |