SCHEMBL3657207

SCHEMBL3657207

O=C(O)c1cc(CC(c2ccc(F)cc2Cl)C(O)C(F)(F)F)ccn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 1/20 0.43
KMO O15229 3/20 0.36
CTSA P10619 1/20 0.35
ALDH1A1 P00352 3/20 0.34
ALOX15 P16050 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
HSD17B10 Q99714 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CYP4F2 P78329 2/20 0.34
CYP4A11 Q02928 2/20 0.34
KDM4C Q9H3R0 2/20 0.33
KDM4E B2RXH2 2/20 0.33
KDM6B O15054 1/20 0.33
TET3 O43151 1/20 0.33
KDM4A O75164 1/20 0.33
BBOX1 O75936 1/20 0.33
MAPT P10636 1/20 0.33
KDM5A P29375 1/20 0.33
KDM5C P41229 1/20 0.33
ASPH Q12797 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3656229 0.88 ALDH1A1 (0.38) MRGPRX4CTSAALDH1A1ALOX15NPSR1
SCHEMBL3656161 0.85 P4HTM (0.40) ALDH1A1ALOX15L3MBTL1KDM4EMAPT
SCHEMBL3651279 0.83 KMO (0.39) MRGPRX4KMOKDM4CKDM4AKDM5A
SCHEMBL3657608 0.83 EIF4E (0.36) KMOKDM4CLOXL2
SCHEMBL3659842 0.82 KMO (0.36) MRGPRX4KMOLOXL2MDM2
SCHEMBL3659044 0.77 MRGPRX4 (0.38) MRGPRX4MDM2MDM4CNR2
SCHEMBL3803786 0.77 MRGPRX4 (0.37) MRGPRX4KMOALDH1A1ALOX15NPSR1
SCHEMBL3653818 0.75 CDC7 (0.38) MRGPRX4ALDH1A1HSD17B10L3MBTL1CYP4F2
SCHEMBL3659001 0.74 TDP1 (0.40) ALDH1A1KDM4EMAPT
SCHEMBL3658244 0.74 CDC7 (0.37) MRGPRX4ALDH1A1NPSR1HSD17B10L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2205562-A1 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES F. Hoffmann-Roche AG (CH) 2010-07-14 EP claimed
WO-2009040288-A1 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-04-02 WO claimed
EP-2205562-A1 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES F. Hoffmann-Roche AG (CH) 2010-07-14 EP disclosed
WO-2009040288-A1 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-04-02 WO disclosed