Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3657488 | 0.97 | EEF2K (0.35) | EEF2KIKBKBHSD17B10MAPK1MKNK1 | |
| SCHEMBL3084095 | 0.90 | EEF2K (0.46) | EEF2KIKBKBHSD17B10MAPK1MKNK1 | |
| SCHEMBL3651076 | 0.90 | EEF2K (0.38) | EEF2KIKBKBHSD17B10MAPK1MKNK1 | |
| SCHEMBL3652451 | 0.89 | EEF2K (0.39) | EEF2KIKBKBMAPK1CXCR1CXCR2 | |
| SCHEMBL3655138 | 0.88 | EEF2K (0.40) | EEF2KIKBKBHSD17B10MAPK1MAPK8 | |
| SCHEMBL3656181 | 0.88 | EEF2K (0.40) | EEF2KIKBKBMAPK1ALDH1A1 | |
| SCHEMBL3655949 | 0.87 | ALDH1A1 (0.34) | HSD17B10MAPK8MAPK9KDM4EALDH1A1 | |
| SCHEMBL3648990 | 0.87 | EEF2K (0.38) | EEF2KIKBKBKDM4EALDH1A1 | |
| SCHEMBL3652423 | 0.87 | EEF2K (0.39) | EEF2KIKBKBMAPK1CXCR1CXCR2 | |
| SCHEMBL3651201 | 0.87 | EEF2K (0.40) | EEF2KIKBKBMAPK1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197886-B1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | claimed |
| EP-2197886-A1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-06-23 | — | — | EP | claimed |
| WO-2009049743-A1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2009-04-23 | — | — | WO | claimed |
| EP-2197886-B1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | disclosed |