Thymine

Thymine

SCHEMBL3657360

Cc1c[nH]c(=O)[nH]c1=O.Nc1cc[nH]c(=O)n1.O=c1cc[nH]c(=O)[nH]1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 1/20 0.50
CRBN Q96SW2 1/20 0.45
DYRK1A Q13627 1/20 0.33
ADORA2A P29274 1/20 0.31
ADORA1 P30542 1/20 0.31
MEN1 O00255 2/20 0.30
POLB P06746 2/20 0.30
KMT2A Q03164 2/20 0.30
KDM4E B2RXH2 1/20 0.30
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
NOS3 P29474 1/20 0.30
NOS1 P29475 1/20 0.30
NOS2 P35228 1/20 0.30
MMP2 P08253 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thymine SCHEMBL2476233 0.93 ATAD2 (0.58) ATAD2DYRK1AADORA2AADORA1MEN1
Thymine SCHEMBL536790 0.93 ATAD2 (0.58) ATAD2DYRK1AADORA2AADORA1MEN1
Thymine SCHEMBL7014626 0.89 ATAD2 (0.40) ATAD2CRBN
Adenine SCHEMBL6227731 0.86 ATAD2 (0.37) ATAD2CRBN
Cytosine SCHEMBL432557 0.86 CRBN (0.61) CRBNDYRK1AADORA2AADORA1MMP2
Cytosine SCHEMBL17372200 0.86 CRBN (0.61) CRBNDYRK1AADORA2AADORA1MMP2
Cytosine SCHEMBL21410176 0.86 CRBN (0.61) CRBNDYRK1AADORA2AADORA1MMP2
Adenine SCHEMBL6227732 0.85 PI4KA (0.41) ATAD2CRBNKDM4ELMNACYP1A2
Thymine SCHEMBL5588329 0.85 ATAD2 (0.47) ATAD2DYRK1AADORA2AADORA1MEN1
Thymine SCHEMBL574783 0.84 ATAD2 (0.70) ATAD2CRBNLMNAHTTMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3942051-A1 PROGRAMMABLE EPIGENETIC CONTROL OF GENE EXPRESSION IN PLANTS Sound Agriculture Company (US) 2022-01-26 EP disclosed
WO-2020191072-A1 PROGRAMMABLE EPIGENETIC CONTROL OF GENE EXPRESSION IN PLANTS Sound Agriculture Company (US) 2020-09-24 WO disclosed
EP-3551595-A1 COMPOSITIONS AND METHODS FOR STIMULATING PLANT GROWTH Malteurop Groupe (FR) 2019-10-16 EP disclosed
WO-2018104531-A1 COMPOSITIONS AND METHODS FOR STIMULATING PLANT GROWTH MALTEUROP GROUPE (FR) 2018-06-14 WO disclosed
WO-2013176958-A1 METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACID SEQUENOM, INC. (US) 2013-11-28 WO disclosed
EP-2205073-A1 AZACYTIDINE ANALOGUES AND USES THEREOF Mount Sinai School of Medicine (US) 2010-07-14 EP disclosed
WO-2009042767-A1 AZACYTIDINE ANALOGUES AND USES THEREOF MOUNT SINAI SCHOOL OF MEDICINE (US) 2009-04-02 WO disclosed
EP-1968971-A1 DIOXOLANE DERIVATES FOR THE TREATMENT OF CANCER Clavis Pharma AS (NO) 2008-09-17 EP disclosed
WO-2007067071-A1 DIOXOLANE DERIVATES FOR THE TREATMENT OF CANCER CLAVIS PHARMA AS (NO) 2007-06-14 WO disclosed
EP-1165501-A1 ALKENYL- AND ALKYNYL-CONTAINING METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 2002-01-02 EP disclosed
WO-2000051975-A1 ALKENYL- AND ALKYNYL-CONTAINING METALLOPROTEASE INHIBITORS THE PROCTER & GAMBLE COMPANY (US) 2000-09-08 WO disclosed
WO-1996030344-A9 PYRIMIDINE COMPOUNDS 1999-02-11 WO disclosed
EP-0817773-A2 PYRIMIDINE COMPOUNDS THE SECRETARY OF STATE FOR DEFENCE (GB) 1998-01-14 EP disclosed