Thymine

Thymine

SCHEMBL2476233

Cc1c[nH]c(=O)[nH]c1=O.Cc1c[nH]c(=O)[nH]c1=O.Nc1cc[nH]c(=O)n1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 1/20 0.58
DYRK1A Q13627 1/20 0.37
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
NOS3 P29474 1/20 0.34
NOS1 P29475 1/20 0.34
NOS2 P35228 1/20 0.34
LMNA P02545 2/20 0.33
HTT P42858 2/20 0.33
DPYD Q12882 2/20 0.33
ALDH1A1 P00352 2/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
CYP19A1 P11511 1/20 0.33
TSHR P16473 1/20 0.33
THPO P40225 1/20 0.33
MTOR P42345 1/20 0.33
HBB P68871 1/20 0.33
PMP22 Q01453 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thymine SCHEMBL536790 1.00 ATAD2 (0.58) ATAD2DYRK1AADORA2AADORA1NOS3
Thymine SCHEMBL3657360 0.93 ATAD2 (0.50) ATAD2DYRK1AADORA2AADORA1NOS3
Thymine SCHEMBL5588329 0.91 ATAD2 (0.47) ATAD2DYRK1AADORA2AADORA1DPYD
Thymine SCHEMBL13280351 0.89 ATAD2 (0.45) ATAD2DYRK1ALMNAHTTALDH1A1
Guanine SCHEMBL4007020 0.85 ATAD2 (0.41) ATAD2DYRK1ALMNAALDH1A1MAPT
Adenine SCHEMBL4579096 0.85 ATAD2 (0.41) ATAD2
Guanine SCHEMBL23880590 0.84 PNP (0.55) ATAD2ALDH1A1MAPTMEN1KMT2A
Guanine SCHEMBL2526275 0.84 PNP (0.55) ATAD2ALDH1A1MAPTMEN1KMT2A
Guanine SCHEMBL20518478 0.84 PNP (0.55) ATAD2ALDH1A1MAPTMEN1KMT2A
Guanine SCHEMBL17597606 0.84 PNP (0.55) ATAD2ALDH1A1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2058392-B1 DNA FRAGMENT USED IN THE FORM ATTACHED TO 5'-TERMINUS OF PRIMER FOR USE IN AMPLIFICATION REACTION OF NUCLEIC ACID, AND USE THEREOF UNIV OSAKA (JP) 2011-10-12 EP claimed
US-20100015618-A1 DNA FRAGMENT USED AS ATTACHED TO 5' END OF PRIMER USED IN NUCLEIC ACID AMPLIFICATION REACTION AND USE OF DNA FRAGMENT OSAKA UNIVERSITY (JP) 2010-01-21 US claimed
EP-2058392-A1 DNA FRAGMENT USED IN THE FORM ATTACHED TO 5'-TERMINUS OF PRIMER FOR USE IN AMPLIFICATION REACTION OF NUCLEIC ACID, AND USE THEREOF Osaka University (JP) 2009-05-13 EP claimed
US-8911947-B2 DNA fragment used as attached to 5′ end of primer used in nucleic acid amplification reaction and use of DNA fragment FURUKAWA ELECTRIC ADVANCED ENGINEERING CO., LTD. (JP) 2014-12-16 US disclosed
EP-2058392-B1 DNA FRAGMENT USED IN THE FORM ATTACHED TO 5'-TERMINUS OF PRIMER FOR USE IN AMPLIFICATION REACTION OF NUCLEIC ACID, AND USE THEREOF UNIV OSAKA (JP) 2011-10-12 EP disclosed
US-20100015618-A1 DNA FRAGMENT USED AS ATTACHED TO 5' END OF PRIMER USED IN NUCLEIC ACID AMPLIFICATION REACTION AND USE OF DNA FRAGMENT OSAKA UNIVERSITY (JP) 2010-01-21 US disclosed
EP-2058392-A1 DNA FRAGMENT USED IN THE FORM ATTACHED TO 5'-TERMINUS OF PRIMER FOR USE IN AMPLIFICATION REACTION OF NUCLEIC ACID, AND USE THEREOF Osaka University (JP) 2009-05-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100015618-A1 DNA FRAGMENT USED AS ATTACHED TO 5' END OF PRIMER USED IN NUCLEIC ACID AMPLIFICATION REACTION AND USE OF DNA FRAGMENT PCNA, APEX1, RNGTT ATAD2 301/4885DYRK1A 2927/4885ADORA2A 1871/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.