Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.53 |
| ▸ | SCD | O00767 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656211 | 0.90 | ATAD2 (0.52) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3651833 | 0.89 | ATAD2 (0.50) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3652445 | 0.87 | GHSR (0.55) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3656300 | 0.87 | ATAD2 (0.48) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3657765 | 0.87 | ATAD2 (0.48) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3656715 | 0.87 | ATAD2 (0.48) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3655887 | 0.85 | MET (0.54) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3651863 | 0.84 | CSNK1D (0.60) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3654365 | 0.83 | ATAD2 (0.54) | NPC1RAB9AATAD2SCDKMT2A | |
| SCHEMBL3655253 | 0.82 | ATAD2 (0.52) | NPC1RAB9AATAD2SCDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205568-A1 | 6-ARYL/HETEROALKYLOXY BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, APPLICATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS C-MET INHIBITORS | Sanofi-Aventis (FR) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009087305-A1 | 6-ARYL/HETEROALKYLOXY BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, APPLICATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS C-MET INHIBITORS | SANOFI-AVENTIS (FR) | 2009-07-16 | — | — | WO | disclosed |