Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364296 | 0.91 | ALDH1A1 (0.49) | LMNAEGFRSRCKDM4EALDH1A1 | |
| SCHEMBL361357 | 0.88 | EGFR (0.51) | EGFRSRCKDM4EALDH1A1HPGD | |
| SCHEMBL365909 | 0.87 | LMNA (0.45) | POLBLMNAEGFRSRCKDM4E | |
| SCHEMBL366390 | 0.85 | ALDH1A1 (0.45) | POLBLMNAEGFRSRCKDM4E | |
| Potassium Ion SCHEMBL367741 | 0.85 | LMNA (0.44) | POLBLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL364265 | 0.84 | NR4A2 (0.46) | POLBLMNAEGFRSRCKDM4E | |
| SCHEMBL364927 | 0.84 | SRC (0.51) | POLBLMNAEGFRSRCKDM4E | |
| SCHEMBL366488 | 0.83 | NR4A2 (0.45) | POLBLMNAEGFRSRCKDM4E | |
| SCHEMBL366338 | 0.83 | NR4A2 (0.45) | POLBLMNAEGFRSRCKDM4E | |
| SCHEMBL366141 | 0.82 | NR4A2 (0.44) | POLBLMNAEGFRSRCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |