Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658285 | 0.80 | CCNT1 (0.53) | JAK2CCNT1CDK9CDK2CDK5 | |
| SCHEMBL30507464 | 0.79 | GSK3B (0.60) | MAPK1CCNT1CDK9CDK2CDC7 | |
| SCHEMBL28512792 | 0.79 | GSK3B (0.60) | MAPK1CCNT1CDK9CDK2CDC7 | |
| SCHEMBL28497712 | 0.79 | CDK2 (0.52) | CCNT1CDK9CDK2CDC7CCNE1 | |
| SCHEMBL30507501 | 0.79 | CDK2 (0.52) | CCNT1CDK9CDK2CDC7CCNE1 | |
| SCHEMBL15939816 | 0.78 | CHRNA7 (0.55) | CCNT1CDK9CDK2CDK5CDK5R1 | |
| SCHEMBL30507254 | 0.78 | CHRNA7 (0.55) | CCNT1CDK9CDK2CDK5CDK5R1 | |
| SCHEMBL3362587 | 0.74 | HSP90AA1 (0.60) | CCNT1CDK9CDK2CDK5CDK5R1 | |
| SCHEMBL30507329 | 0.74 | HSP90AA1 (0.60) | CCNT1CDK9CDK2CDK5CDK5R1 | |
| SCHEMBL8842473 | 0.74 | PRSS1 (0.48) | MKNK1MKNK2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |