Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653927 | 0.83 | P2RX7 (0.47) | ICMTSRCMAPK8HTTCA2 | |
| SCHEMBL31481088 | 0.83 | P2RX7 (0.47) | ICMTSRCMAPK8HTTCA2 | |
| SCHEMBL24102357 | 0.82 | PARP1 (0.47) | SRCPARP1CSNK2A1MAPK8HTT | |
| SCHEMBL2702114 | 0.82 | ICMT (0.45) | ICMTSRCHTTMEN1KMT2A | |
| SCHEMBL28254697 | 0.81 | ICMT (0.44) | ICMTSRCHTTCA2RAB9A | |
| SCHEMBL1354273 | 0.81 | ALDH1A1 (0.45) | ICMTSRCHTTCA2SMN1; SMN2 | |
| SCHEMBL28188707 | 0.79 | ICMT (0.43) | ICMTSRCHTTKMT2ACA2 | |
| SCHEMBL25382106 | 0.79 | ICMT (0.43) | ICMTSRCHTTNPC1HPGD | |
| SCHEMBL30570712 | 0.78 | TAAR1 (0.52) | ICMTSRCHTTMEN1KMT2A | |
| SCHEMBL1478491 | 0.78 | TAAR1 (0.52) | ICMTSRCHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234966-A2 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | Sanofi-Aventis (FR) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009106708-A2 | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI-AVENTIS (FR) | 2009-09-03 | — | — | WO | disclosed |