Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TMPRSS15 | P98073 | 5/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14164237 | 0.80 | PLAT (0.41) | MEN1KMT2ACHRNB2CHRNA4HCRTR2 | |
| SCHEMBL31706232 | 0.80 | PLAT (0.41) | MEN1KMT2ACHRNB2CHRNA4HCRTR2 | |
| SCHEMBL15376175 | 0.77 | HCRTR2 (0.48) | HCRTR2ALDH1A1 | |
| SCHEMBL31705326 | 0.77 | HCRTR2 (0.48) | HCRTR2ALDH1A1 | |
| SCHEMBL15531201 | 0.75 | HCRTR2 (0.50) | MEN1KMT2AHCRTR2ALDH1A1MAPT | |
| SCHEMBL12709970 | 0.72 | PLAT (0.42) | MEN1KMT2ACHRNB2CHRNA4HPGDS | |
| SCHEMBL11700479 | 0.71 | ALDH1A1 (0.44) | SLC6A2SLC6A3MEN1KMT2ATMPRSS15 | |
| SCHEMBL23512729 | 0.70 | HCRTR2 (0.47) | HCRTR2ALDH1A1MAPT | |
| SCHEMBL4677044 | 0.70 | CHRNB2 (0.53) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL22579415 | 0.69 | HRH3 (0.41) | SLC6A3MEN1KMT2AHCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217588-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009055917-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-05-07 | — | — | WO | disclosed |