Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774283 | 0.78 | HIF1A (0.41) | KIF11MEN1KMT2AGSRMKNK1 | |
| SCHEMBL3658890 | 0.75 | HSP90AA1 (0.54) | CHUKTXNRD1NOX4ALDH1A1CYP1A2 | |
| SCHEMBL5773073 | 0.75 | GSR (0.41) | KIF11MEN1KMT2AGSRMKNK1 | |
| SCHEMBL28186259 | 0.75 | MEN1 (0.39) | KIF11MEN1KMT2AGSRMKNK1 | |
| SCHEMBL28186260 | 0.72 | MAPT (0.45) | KIF11TXNRD1KDM4EALDH1A1POLB | |
| SCHEMBL5773336 | 0.71 | FFAR4 (0.48) | — | |
| SCHEMBL5773409 | 0.70 | MAPT (0.49) | KDM4EMEN1KMT2APTPN1 | |
| SCHEMBL27809403 | 0.67 | CYP2C8 (0.46) | KIF11PIK3CACES2CES1 | |
| SCHEMBL29005864 | 0.67 | KIF11 (0.50) | KIF11KDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL3294022 | 0.66 | KIF11 (0.60) | KIF11CHUKTXNRD1NOX4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |