Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27809428 | 0.82 | MAPK14 (0.49) | MAP4K4 | |
| SCHEMBL27787513 | 0.81 | AURKA (0.45) | TRPV1CYP2C9AKR1C2 | |
| SCHEMBL4075531 | 0.80 | PTPN1 (0.47) | LMNASMN1; SMN2 | |
| SCHEMBL27809418 | 0.79 | KIF11 (0.46) | TRPV1KIF11 | |
| SCHEMBL12466534 | 0.75 | KMO (0.43) | LMNASLC22A12AKR1C3AKR1C2CES2 | |
| SCHEMBL28268214 | 0.72 | KLRK1 (0.50) | CYP2C8MAP4K4BACE1TRPV1 | |
| SCHEMBL27809437 | 0.72 | KMO (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1686231 | 0.72 | TRPV1 (0.61) | TRPV1 | |
| SCHEMBL27787507 | 0.72 | KMO (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17288815 | 0.71 | ALDH1A1 (0.43) | SRD5A2RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101796036-A | 5-Phenylisoxazole-3-carboxamide derivatives as TRPV1 modulators | ORGANON NV | 2010-08-04 | — | — | CN | disclosed |