Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663620 | 0.90 | UTS2R (0.41) | DRD4UTS2RCHRNA7 | |
| SCHEMBL649439 | 0.89 | DRD4 (0.49) | RAB9ADRD4UTS2RKMT2AMEN1 | |
| SCHEMBL3665282 | 0.86 | SLC6A4 (0.41) | RAB9ADRD4KMT2AMEN1NPC1 | |
| SCHEMBL3663526 | 0.86 | AR (0.40) | DRD4UTS2RCHRNA7 | |
| SCHEMBL3665359 | 0.85 | UTS2R (0.45) | DRD4UTS2RCHRNA7 | |
| SCHEMBL3666382 | 0.84 | UTS2R (0.44) | UTS2RCHRNA7 | |
| SCHEMBL4408257 | 0.80 | DRD4 (0.51) | RAB9ADRD4UTS2RNPC1LMNA | |
| SCHEMBL647341 | 0.80 | UTS2R (0.52) | DRD4UTS2R | |
| SCHEMBL3666701 | 0.78 | CHRNA7 (0.45) | DRD4UTS2RCHRNA7 | |
| SCHEMBL649739 | 0.78 | UTS2R (0.51) | UTS2RCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |