Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667429 | 0.90 | SLC6A4 (0.40) | SLC6A4DRD4LPLLIPGSLC6A5 | |
| SCHEMBL648340 | 0.89 | DRD4 (0.50) | SLC6A4RAB9ANPC1DRD4SRPK1 | |
| SCHEMBL3662664 | 0.88 | SLC6A5 (0.46) | SLC6A4DRD4SRPK1SLC6A5 | |
| SCHEMBL3665362 | 0.87 | PRKAA2 (0.40) | SLC6A4DRD4LIPCLIPGSLC6A5 | |
| SCHEMBL3659196 | 0.86 | RAB9A (0.39) | RAB9ANPC1DRD4POLBLPL | |
| SCHEMBL3665902 | 0.86 | AR (0.41) | SLC6A4DRD4SLC6A5 | |
| SCHEMBL3666339 | 0.85 | SLC6A4 (0.40) | SLC6A4DRD4SLC6A5 | |
| SCHEMBL3666568 | 0.85 | PRKAA2 (0.40) | SLC6A4DRD4SLC6A5 | |
| SCHEMBL3668577 | 0.84 | SLC6A5 (0.45) | SLC6A4DRD4SLC6A5 | |
| SCHEMBL648178 | 0.83 | RAB9A (0.46) | SLC6A4RAB9ANPC1DRD4SRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |