Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 7/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 2/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650752 | 0.90 | UTS2R (0.45) | ARUTS2RDRD4 | |
| SCHEMBL3665359 | 0.89 | UTS2R (0.45) | ARUTS2RCHRNA7DRD4EPHX2 | |
| SCHEMBL3666382 | 0.88 | UTS2R (0.44) | ARUTS2RCHRNA7CASRPRKAA2 | |
| SCHEMBL3665902 | 0.87 | AR (0.41) | ARUTS2RDRD4CASRLIPE | |
| SCHEMBL3663620 | 0.86 | UTS2R (0.41) | UTS2RCHRNA7DRD4 | |
| SCHEMBL3659196 | 0.86 | RAB9A (0.39) | UTS2RCHRNA7DRD4 | |
| SCHEMBL4402673 | 0.81 | UTS2R (0.47) | ARUTS2RDRD4HRH1CCR3 | |
| SCHEMBL3669184 | 0.81 | AR (0.39) | ARCASR | |
| SCHEMBL648321 | 0.79 | UTS2R (0.56) | UTS2RDRD4PRKAA2 | |
| SCHEMBL648492 | 0.79 | UTS2R (0.54) | UTS2RDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |