SCHEMBL3659342

SCHEMBL3659342

COc1ccc(C(O)C(C)N)cc1OC

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.66
PPARG P37231 1/20 0.62
PPARD Q03181 1/20 0.62
PPARA Q07869 1/20 0.62
CYP2D6 P10635 1/20 0.56
ADRA2A P08913 1/20 0.56
ADRA1A P35348 1/20 0.56
RECQL P46063 4/20 0.55
TDP1 Q9NUW8 4/20 0.55
KDM4E B2RXH2 4/20 0.55
MAPT P10636 3/20 0.55
KMT2A Q03164 3/20 0.55
HIF1A Q16665 3/20 0.55
LMNA P02545 2/20 0.55
BLM P54132 2/20 0.55
ALOX15 P16050 1/20 0.55
TSHR P16473 1/20 0.55
NFKB1 P19838 1/20 0.55
THPO P40225 1/20 0.55
HSD17B10 Q99714 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10774314 1.00 ACHE (0.66) ACHEPPARGPPARDPPARACYP2D6
SCHEMBL8007936 0.87 PPARG (0.53) ACHEPPARGPPARDPPARACYP2D6
SCHEMBL758673 0.86 PPARG (0.68) ACHEPPARGPPARDPPARAKMT2A
SCHEMBL10343408 0.85 PPARG (0.66) ACHEPPARGPPARDPPARAKMT2A
SCHEMBL30366304 0.85 PPARG (0.66) ACHEPPARGPPARDPPARAKMT2A
SCHEMBL28957718 0.85 PPARG (0.66) ACHEPPARGPPARDPPARAKMT2A
SCHEMBL3111714 0.84 RECQL (0.50) ACHEPPARGPPARDPPARACYP2D6
SCHEMBL11274741 0.84 ADRA1A (0.51) ACHEPPARGPPARDPPARACYP2D6
SCHEMBL835288 0.82 RECQL (0.47) ACHEPPARGPPARDPPARACYP2D6
SCHEMBL836490 0.82 RECQL (0.47) ACHEPPARGPPARDPPARACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2222629-A1 PROCESS FOR PREPARING N-METHYL-3, 4 DIMETHOXYPHENYLETHYLAMINE Sicor, Inc. (US) 2010-09-01 EP disclosed
WO-2009086464-A1 PROCESS FOR PREPARING N-METHYL-3, 4 DIMETHOXYPHENYLETHYLAMINE SICOR INC. (US) 2009-07-09 WO disclosed
US-4186129-A CENTRAL NERVOUS SYSTEM DEPRESSANTS, ANTICONVULSANTS SCHERING AKTIENGESELLSCHAFT (DE) 1980-01-29 US disclosed