Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7728775 | 0.83 | ALDH1A1 (0.43) | PARP14ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL6326388 | 0.79 | ALDH1A1 (0.65) | PARP14ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL10966556 | 0.75 | ALDH1A1 (0.53) | PARP14ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL692795 | 0.74 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2HPGDMAOA | |
| SCHEMBL3088335 | 0.73 | IKBKB (0.45) | ALDH1A1KDM4ESMN1; SMN2HPGDPARP1 | |
| SCHEMBL2636302 | 0.73 | BCAT2 (0.53) | ALDH1A1SMN1; SMN2HPGDCYP2C19CYP3A4 | |
| SCHEMBL19448679 | 0.73 | ALDH1A1 (0.54) | PARP14ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL28776030 | 0.73 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2HPGDMAOA | |
| SCHEMBL16429257 | 0.72 | ALDH1A1 (0.57) | PARP14ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL9871137 | 0.72 | ALDH1A1 (0.49) | PARP14ALDH1A1KDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642788-B2 | Activators of executioner procaspases 3, 6 and 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-04 | — | — | US | disclosed |
| EP-2237784-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | The Regents of the University of California (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009089508-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | WO | disclosed |