Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326388 | 0.88 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4ESMN1; SMN2MAOA | |
| SCHEMBL463597 | 0.84 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP2C19HDAC1HDAC3 | |
| SCHEMBL29904721 | 0.84 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP2C19HDAC1HDAC3 | |
| SCHEMBL17796923 | 0.83 | HDAC3 (0.50) | ALDH1A1HPGDKDM4EHDAC1CYP2C9 | |
| Hydrochloric Acid SCHEMBL11503558 | 0.82 | HDAC1 (0.59) | ALDH1A1HPGDSMN1; SMN2CYP2C19HDAC1 | |
| SCHEMBL25066473 | 0.82 | HDAC3 (0.45) | ALDH1A1HPGDKDM4ESMN1; SMN2HDAC1 | |
| SCHEMBL20458594 | 0.82 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4ESMN1; SMN2MAOA | |
| SCHEMBL16429257 | 0.81 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4ESMN1; SMN2MAOA | |
| SCHEMBL7455097 | 0.79 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4EMAOACYP2C19 | |
| SCHEMBL5623725 | 0.79 | ALDH1A1 (0.71) | ALDH1A1HPGDKDM4ESMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170305846-A1 | 2,2' -DIAMINOBIARYLS HAVING A PHTHALOYL GROUP OR SUCCINOYL GROUP | EVONIK DEGUSSA GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
| US-20170305846-A1 | 2,2' -DIAMINOBIARYLS HAVING A PHTHALOYL GROUP OR SUCCINOYL GROUP | EVONIK DEGUSSA GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
| US-20170298013-A1 | 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | EVONIK DEGUSSA GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170298013-A1 | 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | EVONIK DEGUSSA GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170291871-A1 | 2,2' -DIAMINOBIARYLS HAVING ONE PRIMARY AND ONE SECONDARY AMINE | EVONIK DEGUSSA GMBH (DE) | 2017-10-12 | — | — | US | disclosed |
| US-20170291871-A1 | 2,2' -DIAMINOBIARYLS HAVING ONE PRIMARY AND ONE SECONDARY AMINE | EVONIK DEGUSSA GMBH (DE) | 2017-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298013-A1 | 2,2' -DIAMINO BIARYLS WITH TWO SECONDARY AMINES AND PRODUCTION THEREOF BY ELECTROCHEMICAL COUPLING | PM20D2, XDH, DAO | ALDH1A1 408/4885HPGD 3023/4885KDM4E 2129/4885 |
| US-20170291871-A1 | 2,2' -DIAMINOBIARYLS HAVING ONE PRIMARY AND ONE SECONDARY AMINE | SAT1, AOC1, DDT | ALDH1A1 480/4885HPGD 4484/4885KDM4E 3159/4885 |
| US-20170305846-A1 | 2,2' -DIAMINOBIARYLS HAVING A PHTHALOYL GROUP OR SUCCINOYL GROUP | SUCLA2, SPATS2L, SUCLG2 | ALDH1A1 673/4885HPGD 3461/4885KDM4E 1367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.