Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661317 | 0.94 | HRH3 (0.43) | HRH3CYP3A4JAK3KDRALOX5 | |
| Trifluoroacetic Acid SCHEMBL3655804 | 0.86 | CYP1A2 (0.36) | KMT2A | |
| Trifluoroacetic Acid SCHEMBL3660920 | 0.85 | HRH3 (0.38) | HRH3JAK3 | |
| SCHEMBL3658860 | 0.84 | JAK3 (0.43) | HRH3JAK3 | |
| Trifluoroacetic Acid SCHEMBL3655792 | 0.80 | MAPT (0.37) | SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL3651075 | 0.80 | CYP1A2 (0.40) | CYP3A4MEN1ALDH1A1HTTKMT2A | |
| SCHEMBL3660320 | 0.79 | HRH3 (0.41) | HRH3EPHX2MEN1ALDH1A1HTT | |
| SCHEMBL3657582 | 0.79 | HRH3 (0.41) | HRH3JAK3MEN1ALDH1A1HTT | |
| Trifluoroacetic Acid SCHEMBL3654963 | 0.78 | — | — | |
| Trifluoroacetic Acid SCHEMBL3654252 | 0.78 | FLT3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215058-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009052068-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |