Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662226 | 0.85 | EPHX1 (0.49) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3661317 | 0.84 | HRH3 (0.43) | HRH3HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3655137 | 0.83 | RAB9A (0.43) | RAB9ANPC1KMT2AMEN1EPHX2 | |
| SCHEMBL1729647 | 0.81 | EPHX2 (0.38) | HTTEPHX1EPHX2TSHRALDH1A1 | |
| SCHEMBL3658091 | 0.81 | NPC1 (0.53) | HRH3HTTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3658188 | 0.81 | BCL9 (0.41) | RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3651913 | 0.81 | BCL9 (0.41) | RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3653649 | 0.81 | BCL9 (0.41) | RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3659607 | 0.81 | LMNA (0.33) | HRH3HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3656321 | 0.79 | KCNH2 (0.44) | HRH3HTTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215058-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-11 | — | — | EP | claimed |
| WO-2009052068-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | claimed |
| EP-2215058-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009052068-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |