Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6473378 | 0.80 | ESR1 (0.38) | HSD17B10TSHRHIF1ATDP1LMNA | |
| SCHEMBL14847516 | 0.73 | TRPA1 (0.45) | FFAR2TSHRLMNAHPGDALDH1A1 | |
| SCHEMBL15952332 | 0.73 | TRPA1 (0.45) | FFAR2TSHRLMNAHPGDALDH1A1 | |
| SCHEMBL13036602 | 0.72 | AKT1 (0.50) | AKT1PRKD3PRKCGPRKCBBRAF | |
| SCHEMBL10058171 | 0.72 | AKT1 (0.50) | AKT1PRKD3PRKCGPRKCBBRAF | |
| SCHEMBL12798108 | 0.72 | AKT1 (0.50) | AKT1PRKD3PRKCGPRKCBBRAF | |
| SCHEMBL11112508 | 0.71 | FFAR2 (0.42) | AKT1HSD17B10FFAR2TSHRMAPK1 | |
| SCHEMBL15951835 | 0.70 | HDAC4 (0.43) | FFAR2TSHRLMNAHPGDBRD4 | |
| SCHEMBL13900835 | 0.68 | AKT1 (0.63) | AKT1PRKD3PRKCGPRKCBBRAF | |
| SCHEMBL96817 | 0.67 | ADRB2 (0.50) | HSD17B10FFAR2TSHRMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217239-A2 | MODULATION OF PROTEIN TRAFFICKING | Foldrx Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009062118-A2 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |