Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPY2R | P49146 | 4/20 | 0.48 |
| ▸ | MTTP | P55157 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658143 | 0.84 | MGLL (0.46) | NPY2RPOLB | |
| SCHEMBL5081473 | 0.83 | NPY2R (0.70) | HPGDSMN1; SMN2GAANPY2RMTTP | |
| SCHEMBL5079838 | 0.83 | NPY2R (0.67) | GAANPY2RMTTP | |
| SCHEMBL3656158 | 0.81 | ALDH1A1 (0.59) | HPGDTSHRSMN1; SMN2NPC1ALOX15 | |
| SCHEMBL3659972 | 0.81 | KMT2A (0.55) | HPGDTSHRSMN1; SMN2NPC1ALOX15 | |
| SCHEMBL30903881 | 0.80 | GAA (0.53) | HPGDTSHRSMN1; SMN2NPC1TP53 | |
| SCHEMBL29968697 | 0.79 | MAPT (0.49) | HPGDSMN1; SMN2TP53GAANPY2R | |
| SCHEMBL6803523 | 0.79 | MAPT (0.49) | HPGDSMN1; SMN2TP53GAANPY2R | |
| SCHEMBL13873642 | 0.79 | NPY2R (0.44) | HPGDTSHRNPC1ALOX15MAPK1 | |
| SCHEMBL3658547 | 0.76 | ALDH1A1 (0.56) | HPGDSMN1; SMN2MAPK1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101827595-B | Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor | NOVARTIS AG | 2013-07-24 | — | — | CN | claimed |
| CN-101827595-B | Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor | NOVARTIS AG | 2013-07-24 | — | — | CN | disclosed |
| CN-101827595-A | Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor | NOVARTIS AG | 2010-09-08 | — | — | CN | disclosed |
| EP-2205561-A2 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | Novartis Ag (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009050197-A2 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | NOVARTIS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
| US-20090099199-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099199-A1 | ORGANIC COMPOUNDS | SLCO4C1, SLC10A6, SLCO1B1 | HPGD 1477/4885TSHR 3912/4885SMN1; SMN2 4082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.