SCHEMBL3661037

SCHEMBL3661037

COc1ccc(F)cc1C(C)(CF)CC(O)(Cc1cccc(C(F)(F)F)c1F)C(F)F

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 19/20 0.48
NR3C2 P08235 12/20 0.48
PGR P06401 5/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3655483 0.83 NR3C1 (0.48) NR3C1NR3C2PGR
SCHEMBL14158683 0.80 NR3C1 (0.46) NR3C1NR3C2PGR
SCHEMBL291678 0.78 NR3C1 (0.74) NR3C1NR3C2PGR
SCHEMBL27774891 0.75 NR3C1 (0.41) NR3C1NR3C2PGR
SCHEMBL6668738 0.74 NR3C1 (0.47) NR3C1NR3C2PGR
SCHEMBL676013 0.73 NR3C1 (0.53) NR3C1NR3C2PGR
SCHEMBL4471871 0.72 NR3C1 (0.46) NR3C1NR3C2PGR
SCHEMBL9987223 0.71 NR3C1 (0.67) NR3C1NR3C2PGR
SCHEMBL3688034 0.71 NR3C1 (0.67) NR3C1NR3C2PGR
SCHEMBL4447862 0.71 NR3C1 (0.71) NR3C1NR3C2PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012170175-A1 COMPOSITIONS AND METHODS FOR TREATING, CONTROLLING, REDUCING, OR AMELIORATING INFLAMMATORY PAIN BAUSCH & LOMB INCORPORATED (US) 2012-12-13 WO disclosed
EP-2203160-A1 PHARMACOLOGICAL ADJUNCTIVE TREATMENT ASSOCIATED WITH GLAUCOMA FILTRATION SURGERY Bausch & Lomb Incorporated (US) 2010-07-07 EP disclosed
WO-2009042377-A1 PHARMACOLOGICAL ADJUNCTIVE TREATMENT ASSOCIATED WITH GLAUCOMA FILTRATION SURGERY BAUSCH & LOMB INCORPORATED (US) 2009-04-02 WO disclosed