Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471865 | 0.80 | NR3C1 (0.71) | NR3C1NR3C2PGR | |
| SCHEMBL4471868 | 0.78 | NR3C1 (0.56) | NR3C1MAPK1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8877327 | 0.72 | DRD2 (0.62) | MAPK1ALDH1A1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3661037 | 0.72 | NR3C1 (0.48) | NR3C1NR3C2PGR | |
| SCHEMBL4467436 | 0.71 | NR3C1 (0.70) | NR3C1NR3C2PGR | |
| SCHEMBL6668738 | 0.71 | NR3C1 (0.47) | NR3C1NR3C2PGR | |
| SCHEMBL14158683 | 0.70 | NR3C1 (0.46) | NR3C1NR3C2PGR | |
| SCHEMBL4483501 | 0.70 | NR3C1 (0.71) | NR3C1NR3C2PGR | |
| SCHEMBL3655483 | 0.70 | NR3C1 (0.48) | NR3C1NR3C2PGR | |
| SCHEMBL13254564 | 0.70 | DRD2 (0.66) | MAPK1ALDH1A1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579469-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-08-25 | — | — | US | disclosed |