Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | KLK7 | P49862 | 2/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661274 | 1.00 | HDAC8 (0.42) | HDAC8HDAC1KLK7KLK5CAPN1 | |
| SCHEMBL3654901 | 0.88 | CAPN1 (0.39) | HDAC8HDAC1CAPN1BCHEACHE | |
| SCHEMBL20355987 | 0.88 | CTSK (0.42) | HDAC1KLK7KLK5TDP1MEN1 | |
| SCHEMBL3754005 | 0.87 | TDP1 (0.48) | KLK7KLK5TDP1MEN1KMT2A | |
| SCHEMBL9931542 | 0.87 | TDP1 (0.48) | KLK7KLK5TDP1MEN1KMT2A | |
| SCHEMBL29400712 | 0.87 | TDP1 (0.48) | KLK7KLK5TDP1MEN1KMT2A | |
| SCHEMBL1739335 | 0.86 | EPHX2 (0.38) | HDAC8HDAC1TDP1MEN1KMT2A | |
| SCHEMBL2838292 | 0.86 | EPHX2 (0.38) | HDAC8HDAC1TDP1MEN1KMT2A | |
| SCHEMBL3735243 | 0.85 | CAPN1 (0.40) | HDAC8HDAC1CAPN1BCHEACHE | |
| SCHEMBL22402814 | 0.85 | NPSR1 (0.47) | HDAC8HDAC1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217621-B1 | INSULIN DERIVATIVE | NOVO NORDISK AS (DK) | 2015-04-22 | — | — | EP | disclosed |
| US-8710000-B2 | Insulin derivative | NOVO NORDISK A/S (DK) | 2014-04-29 | — | — | US | disclosed |
| US-20100279931-A1 | Insulin Derivative | NOVO NORDISK A/S | 2010-11-04 | — | — | US | disclosed |
| EP-2217621-A1 | INSULIN DERIVATIVE | Novo Nordisk A/S (DK) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060071-A1 | INSULIN DERIVATIVE | NOVO NORDISK A/S (DK) | 2009-05-14 | — | — | WO | disclosed |
| EP-2058330-A1 | Insulin derivative | NOVO NORDISK A/S (DK) | 2009-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279931-A1 | Insulin Derivative | IAPP, INSR, GPR119 | HDAC8 3105/4885HDAC1 3738/4885KLK7 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.