Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 8/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1862935 | 0.79 | AVPR1A (0.46) | MAPK1AVPR1APIM1 | |
| SCHEMBL8764748 | 0.79 | MAPK1 (0.42) | MAPK1EPHX2AVPR1ADRD2MAPK10 | |
| SCHEMBL9672935 | 0.77 | GAA (0.38) | MAPK1EPHX2MEN1KMT2A | |
| SCHEMBL975814 | 0.77 | MAPK1 (0.60) | MAPK1EPHX2AVPR1ABCHE | |
| SCHEMBL29505992 | 0.77 | MAPK1 (0.60) | MAPK1EPHX2AVPR1ABCHE | |
| SCHEMBL29986227 | 0.77 | DRD2 (0.47) | DRD2MEN1KMT2ASCN9ALIPE | |
| SCHEMBL1862101 | 0.74 | DRD2 (0.40) | DRD2MEN1KMT2ALIPE | |
| SCHEMBL10701077 | 0.73 | GAA (0.35) | MAPK1EPHX2MAPK10MEN1KMT2A | |
| SCHEMBL1858653 | 0.73 | DRD2 (0.39) | DRD2MEN1KMT2ABCHELIPE | |
| SCHEMBL26945313 | 0.72 | MAPK1 (0.54) | MAPK1EPHX2AVPR1ASCN9AAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238126-B1 | DERIVATIVES OF TETRAHYDROQUINOXALINE UREA, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2014-11-05 | — | — | EP | disclosed |
| EP-2238126-A2 | DERIVATIVES OF TETRAHYDROQUINOXALINE UREA, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | Sanofi-Aventis (FR) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009112691-A2 | DERIVATIVES OF TETRAHYDROQUINOXALINE UREA, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2009-09-17 | — | — | WO | disclosed |