Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16718396 | 0.81 | BUB1 (0.40) | MAPK1EPHX2SCN9ABRPF1AVPR1A | |
| SCHEMBL5638613 | 0.80 | L3MBTL1 (0.49) | EPHX2SCN9AMEN1KMT2ALIPE | |
| SCHEMBL3661398 | 0.79 | MAPK1 (0.50) | MAPK1EPHX2MAPK10SCN9AMEN1 | |
| SCHEMBL7795540 | 0.78 | L3MBTL1 (0.44) | SCN9AMEN1KMT2ALIPENR1I3 | |
| SCHEMBL4413239 | 0.76 | NOTUM (0.47) | EPHX2SCN9AMEN1KMT2ADRD2 | |
| SCHEMBL19959701 | 0.73 | NFKB1 (0.40) | MEN1KMT2A | |
| SCHEMBL4420583 | 0.72 | CASP6 (0.40) | EPHX2SCN9AMEN1KMT2ADRD2 | |
| SCHEMBL31160375 | 0.71 | NFKB1 (0.38) | MAPK1MEN1KMT2A | |
| SCHEMBL29505992 | 0.69 | MAPK1 (0.60) | MAPK1EPHX2AVPR1ABCHE | |
| SCHEMBL975814 | 0.69 | MAPK1 (0.60) | MAPK1EPHX2AVPR1ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784628-A1 | INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | Vertex Pharmaceuticals Incorporated (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1995035308-A1 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-12-28 | — | — | WO | disclosed |