Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1788116 | 0.77 | ALDH1A1 (0.57) | KMT2AKDM4ETSHRALDH1A1HPGD | |
| SCHEMBL28176203 | 0.76 | HSD17B10 (0.51) | HSD17B10KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL27973180 | 0.76 | HSD17B10 (0.56) | HSD17B10KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL822675 | 0.76 | L3MBTL1 (0.56) | HSD17B10KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL5487133 | 0.74 | PDE5A (0.54) | HSD17B10KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL4858983 | 0.74 | CCNA2 (0.42) | HSD17B10KMT2AALDH1A1PTGER1ADORA2A | |
| SCHEMBL11888546 | 0.73 | PTGER1 (0.54) | HSD17B10KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL628648 | 0.72 | KDM4E (0.42) | HSD17B10KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL13019677 | 0.72 | KMT2A (0.49) | HSD17B10KMT2AKDM4ETSHRALDH1A1 | |
| SCHEMBL17322911 | 0.72 | HSD17B10 (0.64) | HSD17B10KMT2AKDM4ETSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227464-A1 | DERIVATIVES OF 1-[(IMIDAZOLIDIN-2-YL)IMINO)]INDAZOLE | Imperial Innovations Limited (GB) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009071906-A1 | DERIVATIVES OF 1-[(IMIDAZOLIDIN-2-YL)IMINO)]INDAZOLE | IMPERIAL INNOVATIONS LIMITED (GB) | 2009-06-11 | — | — | WO | disclosed |
| WO-2002010137-A9 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARM INC (US) | 2003-02-06 | — | — | WO | disclosed |