Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | TEK | Q02763 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661678 | 0.82 | SIRT2 (0.47) | SIRT2SIRT1SIRT3ALDH1A1KDM4E | |
| SCHEMBL7512451 | 0.81 | PARP10 (0.48) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| Carbamic Acid SCHEMBL12079192 | 0.75 | ALDH1A1 (0.58) | SIRT2SIRT1SIRT3ALDH1A1KDM4E | |
| SCHEMBL7020144 | 0.74 | KDM4E (0.47) | KDM4ETDP1HSD17B10GAAMAPK1 | |
| SCHEMBL27944963 | 0.72 | PARP10 (0.46) | ALDH1A1TDP1MEN1KMT2AAURKA | |
| SCHEMBL28578209 | 0.72 | KMT2A (0.61) | SIRT2SIRT1SIRT3ALDH1A1KDM4E | |
| SCHEMBL3661679 | 0.70 | SIRT2 (0.49) | SIRT2SIRT1SIRT3ALDH1A1KDM4E | |
| SCHEMBL16487053 | 0.70 | FYN (0.47) | ALDH1A1HSD17B10GAAMAPTMAPK8 | |
| Sulfuric Acid SCHEMBL30659034 | 0.69 | ALDH1A1 (0.50) | SIRT2SIRT1SIRT3ALDH1A1KDM4E | |
| Sulfuric Acid SCHEMBL1995909 | 0.69 | ALDH1A1 (0.50) | SIRT2SIRT1SIRT3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152671-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008142454-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |