Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661674 | 0.82 | SIRT2 (0.47) | SIRT2SIRT1SIRT3ALDH1A1KMT2A | |
| SCHEMBL7512439 | 0.81 | PARP10 (0.48) | ALDH1A1KMT2AMEN1TRPA1MAPK1 | |
| SCHEMBL8568267 | 0.79 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL3667423 | 0.76 | SIRT2 (0.36) | SIRT2SIRT1SIRT3ALDH1A1KMT2A | |
| SCHEMBL14353384 | 0.74 | POLB (0.54) | SIRT3KDM4ETDP1HSD17B10 | |
| SCHEMBL3661679 | 0.73 | SIRT2 (0.49) | SIRT2SIRT1SIRT3ALDH1A1KMT2A | |
| Carbamic Acid SCHEMBL12079192 | 0.71 | ALDH1A1 (0.58) | SIRT2SIRT1SIRT3ALDH1A1KMT2A | |
| SCHEMBL2784042 | 0.71 | NR4A1 (0.51) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL1884690 | 0.70 | TRPA1 (0.48) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL4642088 | 0.70 | TSHR (0.50) | ALDH1A1KMT2AMEN1TP53BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152671-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008142454-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |