Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CD38 | P28907 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28578209 | 0.77 | KMT2A (0.61) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL30530111 | 0.74 | MAPK14 (0.42) | PARP1 | |
| SCHEMBL29903108 | 0.74 | NNMT (0.54) | SIRT3PARP1MEN1KMT2AALDH1A1 | |
| SCHEMBL5013567 | 0.74 | NNMT (0.54) | SIRT3PARP1MEN1KMT2AALDH1A1 | |
| Carbamic Acid SCHEMBL12079192 | 0.73 | ALDH1A1 (0.58) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL3661678 | 0.73 | SIRT2 (0.47) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL7673688 | 0.72 | ESRRA (0.46) | ALDH1A1HSD17B10GAAPGRPTGS1 | |
| SCHEMBL14399025 | 0.71 | MAPT (0.49) | MEN1KMT2AALDH1A1GAAKDM4E | |
| SCHEMBL3661674 | 0.70 | SIRT2 (0.47) | SIRT2SIRT1SIRT3MEN1KMT2A | |
| SCHEMBL27256638 | 0.69 | KMT2A (0.60) | SIRT2SIRT1SIRT3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152671-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008142454-A1 | BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | WO | disclosed |