Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.44 |
| ▸ | HTR1E | P28566 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951141 | 0.90 | HTR1D (0.41) | HTR1DHTR1EHTR1AROCK2CDK7 | |
| SCHEMBL3211442 | 0.88 | HTR1D (0.46) | HTR1DHTR1EHTR1AROCK2CDK7 | |
| SCHEMBL3214716 | 0.83 | NOS3 (0.46) | HTR1DHTR1EHTR1ACDK7CDK9 | |
| SCHEMBL3217678 | 0.82 | CDK7 (0.45) | HTR1DHTR1EHTR1AROCK2CDK7 | |
| SCHEMBL3214861 | 0.79 | JAK3 (0.39) | HTR1DHTR1EHTR1AROCK2CDK7 | |
| SCHEMBL3653965 | 0.78 | HTR1D (0.41) | HTR1DHTR1EHTR1ACDK7CDK9 | |
| SCHEMBL3216008 | 0.77 | JAK2 (0.44) | HTR1DHTR1EHTR1ACDK7CDK9 | |
| SCHEMBL3348186 | 0.75 | ROCK2 (0.46) | ROCK2CDK7CDK9JAK1KDR | |
| SCHEMBL3227327 | 0.74 | SLC6A4 (0.66) | HTR1DCDK7CDK9SLC6A4KDR | |
| SCHEMBL3211296 | 0.73 | SLC6A4 (0.45) | HTR1DHTR1EHTR1ASLC6A4NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024980-A1 | 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |