Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242462 | 0.83 | ALDH1A1 (0.38) | ALDH1A1ATML3MBTL1KMT2AMAPT | |
| SCHEMBL11173188 | 0.78 | — | — | |
| SCHEMBL10772449 | 0.78 | — | — | |
| SCHEMBL6859608 | 0.73 | KMT2A (0.33) | ALDH1A1ATML3MBTL1KMT2A | |
| SCHEMBL2860551 | 0.68 | — | — | |
| SCHEMBL2287609 | 0.68 | KMT2A (0.33) | ALDH1A1ATML3MBTL1KMT2AMAPT | |
| SCHEMBL2367658 | 0.67 | HPGD (0.51) | ALDH1A1ATML3MBTL1KMT2AMAPT | |
| SCHEMBL2320524 | 0.67 | ALDH1A1 (0.50) | ALDH1A1KMT2AMAPTKDM4ETP53 | |
| SCHEMBL8108909 | 0.67 | NPC1 (0.33) | ALDH1A1ATML3MBTL1KMT2AMAPT | |
| SCHEMBL8110384 | 0.67 | ALDH1A1 (0.34) | ALDH1A1ATML3MBTL1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231657-A1 | BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY MODULATORS | Abbott Laboratories (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009067579-A1 | BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY MODULATORS | ABBOTT LABORATORIES (US) | 2009-05-28 | — | — | WO | disclosed |