Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11204841 | 0.76 | SMN1; SMN2 (0.47) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL4751172 | 0.76 | MGLL (0.61) | ALDH1A1KMT2AMEN1NPC1GAA | |
| SCHEMBL2859096 | 0.73 | LMNA (0.73) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL3242462 | 0.73 | ALDH1A1 (0.38) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL6629780 | 0.72 | NPC1 (0.56) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL28771220 | 0.72 | KMT2A (0.50) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL5847232 | 0.71 | SMN1; SMN2 (0.57) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL5616625 | 0.71 | KMT2A (0.51) | ALDH1A1MAPTKMT2AMEN1NPC1 | |
| SCHEMBL11796988 | 0.71 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2AMEN1GAA | |
| Phenyl Phenylcarbamate SCHEMBL272994 | 0.70 | ALDH1A1 (0.76) | ALDH1A1MAPTKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531508-A1 | PYRROLO [ 2, 3 - D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | Pfizer Inc. (US) | 2012-12-12 | — | — | EP | disclosed |
| CN-102822177-A | Pyrrolo [ 2, 3 - d] pyrimidine urea compounds as jak inhibitors | PFIZER | 2012-12-12 | — | — | CN | disclosed |
| US-20120309776-A1 | PYRROLO[2,3-D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | PFITZER INC. | 2012-12-06 | — | — | US | disclosed |
| WO-2011097087-A1 | PYRROLO [ 2, 3 - D] PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | PFIZER INC. (US) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309776-A1 | PYRROLO[2,3-D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | JAK3, JAK1, JAK2 | ALDH1A1 3377/4885MAPT 1982/4885KMT2A 1296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.