Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 4/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593293 | 0.87 | CES2 (0.45) | SRD5A2NR1H3NR1H2RXRARXRB | |
| SCHEMBL1333906 | 0.87 | LCK (0.43) | SRD5A2NR1H3NR1H2RXRARXRB | |
| Hydrochloric Acid SCHEMBL15948160 | 0.85 | LCK (0.42) | SRD5A2NR1H3NR1H2RXRARXRB | |
| SCHEMBL494019 | 0.83 | NOTUM (0.64) | NOTUMPOLBHCAR2P2RY14TTR | |
| SCHEMBL1332001 | 0.80 | AR (0.41) | NOTUMNR1H3NR1H2MLYCDRORC | |
| SCHEMBL23411745 | 0.80 | NOTUM (0.51) | NOTUMPOLBHCAR2P2RY14TTR | |
| SCHEMBL29728800 | 0.80 | NOTUM (0.51) | NOTUMPOLBHCAR2P2RY14TTR | |
| SCHEMBL23411618 | 0.80 | NOTUM (0.51) | NOTUMPOLBHCAR2P2RY14TTR | |
| SCHEMBL29728806 | 0.80 | NOTUM (0.51) | NOTUMPOLBHCAR2P2RY14TTR | |
| SCHEMBL3072277 | 0.78 | NOTUM (0.45) | NOTUMPOLBHCAR2P2RY14TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215049-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | Merck Sharp & Dohme Corp. (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009058298-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK & CO., INC. (US) | 2009-05-07 | — | — | WO | disclosed |