SCHEMBL494019

SCHEMBL494019

O=C(O)c1cc(Br)cc(C(F)(F)F)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.64
CES2 O00748 2/20 0.52
RXRA P19793 1/20 0.50
RXRB P28702 1/20 0.50
RXRG P48443 1/20 0.50
TAS2R14 Q9NYV8 1/20 0.48
P2RY14 Q15391 2/20 0.47
SRD5A2 P31213 2/20 0.46
ACP1 P24666 1/20 0.43
MRGPRX4 Q96LA9 2/20 0.43
AKR1C3 P42330 1/20 0.42
AKR1C2 P52895 1/20 0.42
POLB P06746 1/20 0.42
HCAR2 Q8TDS4 1/20 0.42
TTR P02766 1/20 0.42
DDR1 Q08345 2/20 0.41
SLC6A2 P23975 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30688802 0.93 NOTUM (0.57) NOTUMCES2RXRARXRBRXRG
SCHEMBL22400366 0.93 NOTUM (0.57) NOTUMCES2RXRARXRBRXRG
SCHEMBL25677271 0.93 NOTUM (0.57) NOTUMCES2RXRARXRBRXRG
SCHEMBL22400426 0.87 NOTUM (0.51) NOTUMCES2RXRARXRBRXRG
SCHEMBL30688823 0.87 NOTUM (0.51) NOTUMCES2RXRARXRBRXRG
SCHEMBL503980 0.85 CES2 (0.70) CES2RXRARXRBRXRGP2RY14
SCHEMBL545011 0.85 CES2 (0.62) NOTUMCES2RXRARXRBRXRG
SCHEMBL23411618 0.85 NOTUM (0.51) NOTUMCES2RXRARXRBRXRG
SCHEMBL29728800 0.85 NOTUM (0.51) NOTUMCES2RXRARXRBRXRG
SCHEMBL23411745 0.85 NOTUM (0.51) NOTUMCES2RXRARXRBRXRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 381 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116836081-A Ether epoxy toughening agent and preparation method and application thereof 中国林业科学研究院林产化学工业研究所 2023-10-03 CN claimed
US-20210157242-A1 PHOTORESIST-REMOVING LIQUID AND PHOTORESIST-REMOVING METHOD HUAYING RESEARCH CO., LTD (CN) 2021-05-27 US claimed
EP-3663857-A1 PHOTORESIST STRIPPING SOLUTION AND METHOD OF STRIPPING PHOTORESIST Huaying Research Co., Ltd (CN) 2020-06-10 EP claimed
CN-101565369-B Method for preparing 3-bromine-5-trifluoromethylbenzoic acid JIANGSU KAIYUAN PHARMACEUTICAL CHEMICAL ENGINEERING CO LTD 2012-10-03 CN claimed
CN-101565369-A Method for preparing 3-bromine-5-trifluoromethylbenzoic acid JIANGSU KAIYUAN PHARMACEUTICAL (CN) 2009-10-28 CN claimed
CN-116969925-B Heteroaryl-triazole compounds BAYER AG (DE) 2026-05-26 CN disclosed
EP-4313292-B1 INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS CHIESI FARM SPA (IT) 2026-02-18 EP disclosed
US-12552766-B2 Pesticidally active azole amide compounds SYNGENTA CROP PROTECTION AG (CH) 2026-02-17 US disclosed
US-20260008770-A1 CBL-B INHIBITORS AND METHODS OF USES THEREOF INSILICO MEDICINE IP LTD (HK) 2026-01-08 US disclosed
EP-4558504-A1 CBL-B INHIBITORS AND METHODS OF USES THEREOF Insilico Medicine IP Limited (HK) 2025-05-28 EP disclosed
US-20250154107-A1 3,4-Dihydroisoquinolin-1(2H)-Ones Derivatives as STING Antagonists and the Use Thereof BEIGENE SWITZERLAND GMBH (CH) 2025-05-15 US disclosed
US-20250129052-A1 PYRAZINE COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS BASF SE (DE) 2025-04-24 US disclosed
US-20050004136-A1 Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful as neurokinin receptor modulators PAN KEVIN (US) 2005-01-06 US disclosed
WO-2004099197-A2 SUBSTITUTED OXYARENES, AND USE THEREOF FOR CONTROLLING PESTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2004-11-18 WO disclosed
CN-1483030-A Amidoalkyl-piperidine and amidoalkyl-piperazine derivatives for the treatment of nervous system disorders ����-������ҩƷ��˾ 2004-03-17 CN disclosed
US-20030216577-A1 Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) 2003-11-20 US disclosed
EP-1362840-A1 Process for the preparation of aromatic and heteroaromatic carboxylic acids via catalytic ozonolysis DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) 2003-11-19 EP disclosed
EP-1334098-A2 AMIDOALKYL-PIPERIDINE AND AMIDOALKYL-PIPERAZINE DERIVATIVES FOR TREATING OF NERVOUS SYSTEMS DISORDERS Ortho-Mcneil Pharmaceutical, Inc. (US) 2003-08-13 EP disclosed
US-20020183316-A1 Amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-12-05 US disclosed
WO-2002040466-A2 AMIDOALKYL-PIPERIDINE AND AMIDOALKYL-PIPERAZINE DERIVATIVES FOR TREATING OF NERVOUS SYSTEMS DISORDERS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2002-05-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008770-A1 CBL-B INHIBITORS AND METHODS OF USES THEREOF CBL, CBLC, CBLB NOTUM 3628/4885CES2 562/4885RXRA 1300/4885
US-20250129052-A1 PYRAZINE COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS API5, DDT, PIR NOTUM 1152/4885CES2 4250/4885RXRA 2894/4885
US-20050004136-A1 Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful as neurokinin receptor modulators OPRL1, NPSR1, NPFFR1 NOTUM 3316/4885CES2 3889/4885RXRA 2179/4885
US-12552766-B2 Pesticidally active azole amide compounds DDT, CBR3, CBR1 NOTUM 1473/4885CES2 204/4885RXRA 3539/4885
US-20020183316-A1 Amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders OPRL1, PMP22, FAAH NOTUM 2964/4885CES2 1017/4885RXRA 2573/4885
US-20250154107-A1 3,4-Dihydroisoquinolin-1(2H)-Ones Derivatives as STING Antagonists and the Use Thereof STING1, IRF3, MAVS NOTUM 4771/4885CES2 4707/4885RXRA 2209/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.