Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.46 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493629 | 0.82 | OPRM1 (0.48) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL643255 | 0.81 | TDP1 (0.49) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL493456 | 0.77 | OPRM1 (0.51) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL645187 | 0.76 | OPRM1 (0.48) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL492900 | 0.76 | OPRM1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL7054929 | 0.75 | OPRM1 (0.63) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL643619 | 0.74 | OPRM1 (0.51) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL1328757 | 0.73 | HSD11B1 (0.39) | OPRM1MEN1KMT2A | |
| SCHEMBL643012 | 0.73 | OPRM1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL5028615 | 0.73 | CACNA2D1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |