Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.50 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GALK1 | P51570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18263730 | 0.81 | ALDH1A1 (0.64) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL2907024 | 0.79 | L3MBTL1 (0.46) | L3MBTL1NOTUMRAB9AALDH1A1POLB | |
| SCHEMBL18263808 | 0.79 | LTA4H (0.62) | OPRM1OPRD1OPRK1OPRL1L3MBTL1 | |
| SCHEMBL643255 | 0.78 | TDP1 (0.49) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL28554103 | 0.74 | OPRM1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL11888863 | 0.74 | ALDH1A1 (0.55) | CACNA2D1CACNA1BCACNB1CACNA1COPRM1 | |
| SCHEMBL28468740 | 0.73 | KMT2A (0.55) | OPRM1OPRD1OPRK1OPRL1NOTUM | |
| SCHEMBL28467466 | 0.73 | KMT2A (0.55) | OPRM1OPRD1OPRK1OPRL1NOTUM | |
| SCHEMBL28469518 | 0.73 | KMT2A (0.55) | OPRM1OPRD1OPRK1OPRL1NOTUM | |
| SCHEMBL28467467 | 0.73 | KMT2A (0.55) | OPRM1OPRD1OPRK1OPRL1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280879-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280879-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | XDH, CYP2D6, F12 | CACNA2D1 2285/4885CACNA1B 1503/4885CACNB1 3459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.