Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711198 | 0.85 | LMNA (0.52) | LMNACYP2C19ALDH1A1GAAKMT2A | |
| SCHEMBL1861854 | 0.84 | LMNA (0.51) | LMNACYP2C19ALDH1A1GAAKMT2A | |
| SCHEMBL3662305 | 0.80 | LMNA (0.48) | LMNACYP2C19ALDH1A1CYP2C9MAPT | |
| T-2000 SCHEMBL711204 | 0.73 | LMNA (0.69) | LMNACYP2C19ALDH1A1GAAELANE | |
| SCHEMBL5891181 | 0.72 | ALDH1A1 (0.46) | LMNACYP2C19ALDH1A1GAAMAPT | |
| SCHEMBL13497193 | 0.72 | LMNA (0.43) | LMNACYP2C19CYP1A2MEN1KMT2A | |
| SCHEMBL7599895 | 0.70 | CYP2C19 (0.39) | LMNACYP2C19ALDH1A1GAA | |
| SCHEMBL437784 | 0.69 | HPGD (0.59) | ALDH1A1GAAHPGDMAPTMEN1 | |
| SCHEMBL13002844 | 0.68 | CYP2C19 (0.37) | LMNACYP2C19ALDH1A1GAAKMT2A | |
| SCHEMBL14035379 | 0.66 | LMNA (0.63) | LMNACYP2C19ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140030322-A1 | PHARMACEUTICAL COMPOSITIONS | LOCL PHARMA, INC. | 2014-01-30 | — | — | US | claimed |
| US-20120201888-A1 | Pharmaceutical Compositions | CHARLESTON LABORATORIES, INC. (US) | 2012-08-09 | — | — | US | claimed |
| EP-2240022-A2 | PHARMACEUTICAL COMPOSITIONS | Charleston Laboratories, Inc. (US) | 2010-10-20 | — | — | EP | claimed |
| WO-2009089494-A2 | PHARMACEUTICAL COMPOSITIONS | CHARLESTON LABORATORIES, INC. (US) | 2009-07-16 | — | — | WO | claimed |
| US-20090175939-A1 | PHARMACEUTICAL COMPOSITIONS | CHARLESTON LABORATORIES, INC. (US) | 2009-07-09 | — | — | US | claimed |
| EP-3090743-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATING HEADACHE AND ELIMINATING NAUSEA | Charleston Laboratories, Inc. (US) | 2016-11-09 | — | — | EP | disclosed |