Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14035379 | 0.91 | LMNA (0.63) | LMNACNR1GPR55NPSR1ALDH1A1 | |
| SCHEMBL13002842 | 0.89 | LMNA (0.57) | LMNACNR1GPR55NPSR1NPC1 | |
| SCHEMBL5873336 | 0.83 | LMNA (0.54) | LMNACNR1GPR55NPSR1ELANE | |
| SCHEMBL711198 | 0.82 | LMNA (0.52) | LMNACNR1GPR55ALDH1A1NPC1 | |
| SCHEMBL1861854 | 0.81 | LMNA (0.51) | LMNACNR1GPR55ALDH1A1NPC1 | |
| SCHEMBL13002849 | 0.79 | LMNA (0.46) | LMNACNR1GPR55NPSR1ELANE | |
| SCHEMBL3662305 | 0.77 | LMNA (0.48) | LMNACNR1GPR55ALDH1A1NPC1 | |
| SCHEMBL11278773 | 0.73 | POLB (0.61) | LMNACNR1NPC1POLBMEN1 | |
| SCHEMBL3662307 | 0.73 | LMNA (0.43) | LMNAELANEALDH1A1GAACYP2C19 | |
| SCHEMBL13241901 | 0.71 | LMNA (0.51) | LMNANPC1CYP2C19TSHRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348303-A1 | PHARMACEUTICAL COMPOSITIONS | CHARLESTON LABORATORIES, INC. | 2017-12-07 | — | — | US | claimed |
| US-20140030322-A1 | PHARMACEUTICAL COMPOSITIONS | LOCL PHARMA, INC. | 2014-01-30 | — | — | US | claimed |
| US-20120201888-A1 | Pharmaceutical Compositions | CHARLESTON LABORATORIES, INC. (US) | 2012-08-09 | — | — | US | claimed |
| EP-2240022-A2 | PHARMACEUTICAL COMPOSITIONS | Charleston Laboratories, Inc. (US) | 2010-10-20 | — | — | EP | claimed |
| WO-2009089494-A2 | PHARMACEUTICAL COMPOSITIONS | CHARLESTON LABORATORIES, INC. (US) | 2009-07-16 | — | — | WO | claimed |
| US-20090175939-A1 | PHARMACEUTICAL COMPOSITIONS | CHARLESTON LABORATORIES, INC. (US) | 2009-07-09 | — | — | US | claimed |
| EP-1311270-B1 | NON-SEDATING BARBITURATE COMPOUNDS AS NEUROPROTECTIVE AGENTS | TARO PHARMA IND (IL) | 2008-01-09 | — | — | EP | claimed |
| US-20070167624-A1 | Process for preparing 1-methoxymethyl 5,5-diphenybarbituric acid | TARO PHARMACEUTICAL INDUSTRIES LTD. (US) | 2007-07-19 | — | — | US | claimed |
| US-7227021-B2 | Process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid | TARA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2007-06-05 | — | — | US | claimed |
| EP-1781624-A2 | A PROCESS FOR PREPARING 1-METHOXYMETHYL-5,5-DIPHENYLBARBITURIC ACID | Taro Pharmaceutical Industries Ltd. (IL) | 2007-05-09 | — | — | EP | claimed |
| US-20060004031-A1 | Process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid | TARO PHARMACEUTICAL INDUSTRIES LIMITED (IL) | 2006-01-05 | — | — | US | claimed |
| US-20040224947-A1 | Non-sedating barbiturate compounds as neuroprotective agents | TARO PHARMACEUTICAL INDUSTRIES LTD (IL) | 2004-11-11 | — | — | US | claimed |
| US-20040167358-A1 | Method and reagents for N-alkylating ureides | GUTMAN DANIELA (IL) | 2004-08-26 | — | — | US | claimed |
| US-6756379-B2 | USING SUCH AS 1,3-DIMETHOXYMETHYL-5,5-DIPHENYL-BARBITURIC ACID | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-06-29 | — | — | US | claimed |
| US-20030153589-A1 | Non-sedating barbiturate compounds as neuroprotective agents | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-08-14 | — | — | US | claimed |
| EP-1311270-A1 | NON-SEDATING BARBITURATE COMPOUNDS AS NEUROPROTECTIVE AGENTS | TARO PHARMACEUTICAL INDUSTRIES LIMITED (IL) | 2003-05-21 | — | — | EP | claimed |
| US-20030018080-A1 | N-methoxymethyl-5,5-diphenylbarbituric acid | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-01-23 | — | — | US | claimed |
| WO-2002007729-A9 | NON-SEDATING BARBITURATE COMPOUNDS AS NEUROPROTECTIVE AGENTS | TARO PHARMA IND (IL) | 2002-08-08 | — | — | WO | claimed |
| WO-2002007729-A1 | NON-SEDATING BARBITURATE COMPOUNDS AS NEUROPROTECTIVE AGENTS | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2002-01-31 | — | — | WO | claimed |
| US-6093820-A | REACTING AN IMIDE WITH A (SUBSTITUTED)ALKOXYALKYLSULFONIC ACID ESTER TO FORM A N-ALKOXYALKYL IMIDE SUCH AS METHOXYMETHYL ETHOSUXIMIDE; ADMINISTERING AS ANTICONVULSANT, ANTIANXIETY AGENT AND MUSCLE RELAXANT | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2000-07-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018080-A1 | N-methoxymethyl-5,5-diphenylbarbituric acid | MGMT, ALKBH3, ALKBH5 | LMNA 2679/4885CNR1 801/4885GPR55 1056/4885 |
| US-20040167358-A1 | Method and reagents for N-alkylating ureides | MGMT, ETV6, ALKBH3 | LMNA 2608/4885CNR1 767/4885GPR55 1512/4885 |
| US-20030153589-A1 | Non-sedating barbiturate compounds as neuroprotective agents | GABRB1, GABRB3, GABRB2 | LMNA 2395/4885CNR1 268/4885GPR55 1625/4885 |
| US-20040224947-A1 | Non-sedating barbiturate compounds as neuroprotective agents | GABRB1, GABRB2, GABRB3 | LMNA 2733/4885CNR1 271/4885GPR55 1538/4885 |
| US-20060004031-A1 | Process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid | ALKBH5, KDM5A, ALKBH1 | LMNA 1095/4885CNR1 1424/4885GPR55 870/4885 |
| US-20070167624-A1 | Process for preparing 1-methoxymethyl 5,5-diphenybarbituric acid | ALKBH5, KDM5A, ALKBH1 | LMNA 1594/4885CNR1 1306/4885GPR55 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.