Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.43 |
| ▸ | PDE2A | O00408 | 11/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL969006 | 0.68 | PDE10A (0.50) | PDE10APDE2ALCK | |
| SCHEMBL2791778 | 0.68 | PDE2A (0.53) | PDE10APDE2ALCK | |
| SCHEMBL14341741 | 0.61 | PDE10A (0.36) | PDE10ALCK | |
| SCHEMBL10094685 | 0.58 | ABL1 (0.46) | PDE10APDE2A | |
| SCHEMBL15730180 | 0.56 | MKNK1 (0.47) | PDE10APDE2A | |
| SCHEMBL22232224 | 0.56 | ABL1 (0.43) | PDE10APDE2A | |
| SCHEMBL7979822 | 0.55 | LCK (0.61) | PDE10APDE2ALCK | |
| SCHEMBL10094434 | 0.55 | APP (0.41) | — | |
| SCHEMBL968965 | 0.54 | PDE10A (0.55) | PDE10APDE2APDE5APDE11AADORA2A | |
| SCHEMBL14341743 | 0.53 | PDE10A (0.35) | PDE10ALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225248-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | Wyeth LLC (US) | 2010-09-08 | — | — | EP | claimed |
| WO-2009070584-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2009-06-04 | — | — | WO | claimed |