Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777311 | 0.91 | ALDH1A1 (0.38) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2777556 | 0.84 | PTPN1 (0.43) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL3663664 | 0.82 | PTPN1 (0.41) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2776138 | 0.81 | POLB (0.47) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2779106 | 0.81 | POLB (0.41) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2777595 | 0.78 | TP53 (0.39) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2776688 | 0.77 | MEN1 (0.42) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL3663330 | 0.77 | PTPN1 (0.38) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL2777421 | 0.76 | SLC26A6 (0.43) | PTPN1MAPTPOLBALDH1A1KDM4E | |
| SCHEMBL3657976 | 0.75 | POLB (0.39) | PTPN1MAPTPOLBALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227475-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | Fibrogen, Inc. (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009073669-A1 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS | FIBROGEN, INC. (US) | 2009-06-11 | — | — | WO | disclosed |