Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.42 |
| ▸ | CCR6 | P51684 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661362 | 0.92 | USP30 (0.40) | USP30UCHL1CCR6THRB | |
| SCHEMBL3664020 | 0.92 | THRB (0.41) | USP30UCHL1THRBPRKAA2CYP3A4 | |
| SCHEMBL3664571 | 0.91 | USP30 (0.39) | USP30UCHL1GPR119 | |
| SCHEMBL647468 | 0.89 | THRB (0.51) | USP30UCHL1CCR6THRBPRKAA2 | |
| SCHEMBL3667019 | 0.85 | PRKAA2 (0.49) | PRKAA2CYP3A4RORC | |
| SCHEMBL648845 | 0.83 | LIPE (0.45) | USP30UCHL1THRBPRKAA2CYP3A4 | |
| SCHEMBL647428 | 0.81 | THRB (0.47) | USP30UCHL1CCR6THRB | |
| SCHEMBL648681 | 0.80 | THRB (0.54) | USP30UCHL1THRBPRKAA2CYP3A4 | |
| SCHEMBL12225951 | 0.80 | PRKAA2 (0.46) | USP30UCHL1PRKAA2 | |
| SCHEMBL4401696 | 0.80 | THRB (0.54) | CCR6THRBPRKAA2CYP3A4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |