Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | LIPE | Q05469 | 4/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662714 | 0.91 | USP30 (0.42) | USP30UCHL1GPR119 | |
| SCHEMBL3664020 | 0.89 | THRB (0.41) | USP30UCHL1GPR119F10 | |
| SCHEMBL650729 | 0.88 | LIPE (0.43) | USP30UCHL1LIPEALDH1A1HTR7 | |
| SCHEMBL3661362 | 0.87 | USP30 (0.40) | USP30UCHL1 | |
| SCHEMBL3661407 | 0.84 | SLC6A5 (0.42) | — | |
| SCHEMBL648845 | 0.84 | LIPE (0.45) | USP30UCHL1GPR119LIPEALDH1A1 | |
| SCHEMBL4454172 | 0.82 | USP30 (0.45) | USP30UCHL1SCN3AGPR119LIPE | |
| SCHEMBL12225951 | 0.82 | PRKAA2 (0.46) | USP30UCHL1LIPEHTR7SCN8A | |
| SCHEMBL4401672 | 0.81 | LIPE (0.44) | USP30UCHL1GPR119LIPESCN8A | |
| SCHEMBL10113339 | 0.81 | ALDH1A1 (0.46) | USP30UCHL1SCN3AGPR119LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |