Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357183 | 0.92 | SIRT6 (0.44) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL358224 | 0.86 | CFTR (0.49) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL28723015 | 0.81 | ALDH1A1 (0.45) | SIRT6CFTRPDGFRBFGFR1PDGFRA | |
| SCHEMBL5221908 | 0.78 | ALDH1A1 (0.43) | CFTRTDP1KDM4EALDH1A1GAA | |
| SCHEMBL913705 | 0.78 | PDGFRB (0.46) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL5219938 | 0.76 | ALDH1A1 (0.46) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2522809 | 0.76 | PDGFRB (0.50) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2901232 | 0.75 | TDP1 (0.47) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL1462927 | 0.75 | TDP1 (0.47) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL670584 | 0.75 | PDGFRB (0.47) | SIRT6CFTRPDGFRBFGFR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234989-A1 | TETRAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077371-A1 | TETRAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |