Sugi Predict

Sugi Predict / Compounds / SCHEMBL2522809

SCHEMBL2522809

SCHEMBL2522809

COC(=O)c1cc([N+](=O)[O-])c(F)c(F)c1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDGFRB P09619 1/20 0.50
▸ FGFR1 P11362 1/20 0.50
▸ PDGFRA P16234 1/20 0.50
▸ FLT1 P17948 1/20 0.50
▸ FGFR3 P22607 1/20 0.50
▸ KDR P35968 1/20 0.50
▸ SIRT6 Q8N6T7 1/20 0.44
▸ VCAM1 P19320 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.41
▸ ALDH1A1 P00352 3/20 0.40
▸ LMNA P02545 2/20 0.40
▸ GALR2 O43603 1/20 0.40
▸ MITF O75030 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ HSP90AA1 P07900 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ XBP1 P17861 1/20 0.40
▸ CCR6 P51684 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26962045 0.89 PDGFRB (0.52) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL5212870 0.87 PDGFRB (0.48) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL8079569 0.86 PDGFRB (0.50) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL670584 0.86 PDGFRB (0.47) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL913705 0.85 PDGFRB (0.46) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL23970369 0.84 PDGFRB (0.46) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL30158896 0.84 PDGFRB (0.46) PDGFRBFGFR1PDGFRAFLT1FGFR3
Hydrochloric Acid SCHEMBL7539373 0.84 PDGFRB (0.46) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL5219938 0.84 ALDH1A1 (0.46) PDGFRBFGFR1PDGFRAFLT1FGFR3
SCHEMBL22009916 0.83 SIRT6 (0.47) PDGFRBFGFR1PDGFRAFLT1FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240254136-A1 COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS Redona Therapeutics, Inc. 2024-08-01 — — US disclosed
US-11976083-B2 Inhibitors of peptidylarginine deiminases GILEAD SCIENCES, INC. (US) 2024-05-07 — — US disclosed
CN-115551862-B Macrocyclic inhibitors of peptidyl arginine deiminase 吉利德科学公司 2024-04-12 — — CN disclosed
US-11878965-B2 Inhibitors of peptidylarginine deiminases GILEAD SCIENCES, INC. (US) 2024-01-23 — — US disclosed
EP-4267562-A1 INHIBITORS OF PEPTIDYLARGININE DEIMINASES GILEAD SCIENCES, INC. (US) 2023-11-01 — — EP disclosed
CN-116157392-A Compounds targeting RNA binding proteins or RNA modification proteins 雷多纳治疗公司 2023-05-23 — — CN disclosed
US-20230090053-A1 INHIBITORS OF PEPTIDYLARGININE DEIMINASES GILEAD SCIENCES, INC. 2023-03-23 — — US disclosed
EP-4143189-A1 MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES GILEAD SCIENCES, INC. (US) 2023-03-08 — — EP disclosed
EP-4114831-A1 COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS Twentyeight-Seven, Inc. (US) 2023-01-11 — — EP disclosed
US-20230002412-A1 INHIBITORS OF PEPTIDYLARGININE DEIMINASES GILEAD SCIENCES, INC. 2023-01-05 — — US disclosed
US-8039637-B2 Process for preparing benzimidazole compounds ARRAY BIOPHARMA INC. (US) 2011-10-18 — — US disclosed
US-8039637-B2 Process for preparing benzimidazole compounds ARRAY BIOPHARMA INC. (US) 2011-10-18 — — US disclosed
WO-2010138377-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER MERCK SHARP & DOHME CORP. (US) 2010-12-02 — — WO disclosed
WO-2010138377-A1 COMPOSITIONS AND METHODS FOR TREATING CANCER MERCK SHARP & DOHME CORP. (US) 2010-12-02 — — WO disclosed
US-20100145065-A1 PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS ARRAY BIOPHARMA INC. (US) 2010-06-10 — — US disclosed
US-20100145065-A1 PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS ARRAY BIOPHARMA INC. (US) 2010-06-10 — — US disclosed
US-20100145065-A1 PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS ARRAY BIOPHARMA INC. (US) 2010-06-10 — — US disclosed
EP-1904481-A2 PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS Array Biopharma, Inc. (US) 2008-04-02 — — EP disclosed
WO-2007002157-A2 PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS ARRAY BIOPHARMA INC. (US) 2007-01-04 — — WO disclosed
WO-2007002157-A2 PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS ARRAY BIOPHARMA INC. (US) 2007-01-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230090053-A1 INHIBITORS OF PEPTIDYLARGININE DEIMINASES PADI4, PADI2, PADI1 PDGFRB 2177/4885FGFR1 3868/4885PDGFRA 2983/4885
US-11976083-B2 Inhibitors of peptidylarginine deiminases PADI4, PADI2, PADI1 PDGFRB 2177/4885FGFR1 3868/4885PDGFRA 2983/4885
US-20100145065-A1 PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS CYP2E1, CYP1A1, F12 PDGFRB 2391/4885FGFR1 1554/4885PDGFRA 2226/4885
US-20230002412-A1 INHIBITORS OF PEPTIDYLARGININE DEIMINASES PADI4, PADI2, PADI1 PDGFRB 2177/4885FGFR1 3868/4885PDGFRA 2983/4885
US-20240254136-A1 COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS NSUN3, NSUN2, RBM3 PDGFRB 4186/4885FGFR1 3829/4885PDGFRA 4430/4885
US-11878965-B2 Inhibitors of peptidylarginine deiminases PADI4, PADI2, PADI1 PDGFRB 2177/4885FGFR1 3868/4885PDGFRA 2983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.